Advantix with the active ingredients Permethrin and Imidacloprid is a fast-acting agent that kills fleas, ticks and lice. It is also a remedy that repels ticks, sandflies, mosquitoes and stable flies. These parasites can transmit various diseases to your dog. Advantix's repellent reduces this risk. Advantix is a spot-on anti-flea and tick remedy for dogs and is applied with pipettes. Advantix creates the so-called hot foot effect. Ticks that land on the coat of the treated dog react as if they are walking on a hot plate. They have no time to attach themselves and fall to the ground where they die.